Recent Pharmacological Developments on Rhodanines and 2,4-Thiazolidinediones
نویسندگان
چکیده
Thiazolidines are five-member heterocyclic having sulfur, nitrogen, and oxygen atoms in their ring structure and exhibiting potent as well as wide range of pharmacological activities. In this minireview, recent updates on synthesis and pharmacological evaluations of molecules based on 2,4-thiazolidine and rhodanine are discussed.
منابع مشابه
Review on Recent developments and biological activities of 2, 4-thiazolidinediones
Thiazolidinediones (TZDs) are five-membered heterocyclic having sulfur, nitrogen, and oxygen atoms in their ring structure and exhibiting potent as well as wide range of pharmacological activities. Variety of substituents on the thiazolidine-2,4-dione nucleus or as hybrid molecules when combined with other heterocyclic rings produce wide range of biological activities suchas antihyperglycemics,...
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A series of erythrose, ribose, and substituted pyrrolidine containing 2,4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thiazolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-[4-[2-(1-benzyl-3,4-bis-benzyloxypyrroli...
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A large number of reports have been published in recent years regarding the use of N-carboxymethyl rhodanines as antimicrobial agents. Molecules belonging to this structural class have been reported to exhibit good inhibitory activities towards various Gram-positive bacteria, including several multidrug-resistant strains such as methicillinresistant Staphylococcus aureus and quinolone-resistant...
متن کاملCoden : Ijpnl 6 Qsar Modeling Studies on 2 , 4 - Thiazolidinediones as Potential Α - Glucosidase Inhibitors
A linear quantitative structure-activity relationship (QSAR) model is presented for modeling and predicting the αglucosidase inhibitory activity. The model was produced by using the multiple linear regression (MLR) technique on a twenty one compound database that consists of newly discovered 2,4-thiazolidinediones. The major conclusion of this study is that molecular weight, wiener index, andre...
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عنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013